Authors
Shevchenko Yu.L., Stojko Yu.M., Gudymovich V.G., Chernyago T.Yu.
Pirogov National Medical and Surgical Center, Moscow.
Abstract
The article is devoted to a review of the literature of the history of the discovery and function of glycocalyx, which is part of the endotheliocyte membrane. Based on the analyzed works that have been published in the medical press over the past 30 years, the importance of studying the function and structure of glycocalyx in the endothelial layer of veins is noted. The significant influence of glycocalyx in the development of pathophysiological processes in patients with pathology of the cardiovascular system is presented.
Keywords: glycocalyx, endothelium, endothelial dysfunction, cardiovascular system.
References
1. Shevchenko YuL, Stoyko YuM, Gudymovich VG. Disfunktsiya i povrezhdenie endoteliya (patofiziologiya, diagnostika, klinicheskie proyavleniya i lechenie). Moscow: Lika; 2015. 166 p. (In Russ).
2. Starling EH. On the absorption of fluids from the connective tissue spaces. J Physiol. 1896;19(4):312–326. Doi: 10.1113/jphysiol.1896.sp000596.
3. Weinbaum S. 1997 Whitaker Distinguished Lecture: Models to solve mysteries in biomechanics at the cellular level; a new view of fiber matrix layers. Ann Biomed Eng. 1998;26(4):627–643. Doi: 10.1114/1.134.
4. Michel CC. Starling: the formulation of his hypothesis of microvascular fluid exchange and its significance after 100 years. Exp Physiol. 1997;82(1):1–30. Doi: 10.1113/expphysiol.1997.sp004000.
5. Bennett HS. Morphological aspects of extracellular polysaccharides. J Histochem Cytochem. 1963;11:14–23. Doi: 10.1177/11.1.14.
6. Hooke R. Micrographia — some physiological descriptions of minute bodies made by magnifying glasses with observations and inquiries thereupon. London: John Martin and James Allestry; 1665. Doi: 10.5962/bhl.title.904.
7. Rambourg A, Neutra M, Leblond CP. Presence of a “cell coat” rich in carbohydrate at the surface of cells in the rat. Anat Rec. 1966;154(1):41–71. Doi: 10.1002/ar.1091540105.
8. Vink H, Duling BR. Identification of distinct luminal domains for macromolecules, erythrocytes, and leukocytes within mammalian capillaries. Circ Res. 1996;79(3):581-589. Doi: 10.1161/01.res.79.3.581.
9. Squire JM, Chew M, Nneji G, et al. Quasi-periodic substructure in the microvessel endothelial glycocalyx: a possible explanation for molecular filtering? J Struct Biol. 2001;136(3):239–255. Doi: 10.1006/jsbi.2002.4441.
10. Ainslie KM, Garanich JS, Dull RO, Tarbell JM. Vascular smooth muscle cell glycocalyx influences shear stress-mediated contractile response. J Appl Physiol (1985). 2005;98(1):242–249. Doi: 10.1152/japplphysiol.01006.2003.
11. Kang H, Liu M, Fan Y, Deng X. A potential gravity-sensing role of vascular smooth muscle cell glycocalyx in altered gravitational stimulation. Astrobiology. 2013;13(7):626–636. Doi: 10.1089/ast.2012.0944.
12. Ebong EE, Macaluso FP, Spray DC, et al. Imaging the endothelial glycocalyx in vitro by rapid freezing/freeze substitution transmission electron microscopy. Arterioscler Thromb Vasc Biol. 2011;31(8):1908–1915. Doi: 10.1161/ATVBAHA.111.225268.
13. van den Berg BM, Vink H, Spaan JA. The endothelial glycocalyx protects against myocardial edema. Circ Res. 2003;92(6):592–594. Doi: 10.1161/01.RES.0000065917.53950.75.
14. Gorshkov AYu, Boitsov SA. Endotelial'nyi glikokaliks — potentsial'nyi sosudistyi biomarker: diagnosticheskaya i terapevticheskaya mishen' serdechno-sosudistykh zabolevanii. Kardiovaskulyarnaya terapiya i profilaktika. 2015;14(6);87-92. (In Russ).
15. van den Berg BM, Nieuwdorp M, Stroes ES, Vink H. Glycocalyx and endothelial (dys) function: from mice to men. Pharmacol Rep. 2006;58 Suppl:75–80.
16. Broekhuizen LN, Mooij HL, Kastelein JJ, et al. Endothelial glycocalyx as potential diagnostic and therapeutic target in cardiovascular disease. Curr Opin Lipidol. 2009;20(1):57–62. Doi: 10.1097/MOL.0b013e328321b587.
17. Rehm M, Zahler S, Lötsch M, et al. Endothelial glycocalyx as an additional barrier determining extravasation of 6% hydroxyethyl starch or 5% albumin solutions in the coronary vascular bed. Anesthesiology. 2004;100(5):1211–1223. Doi: 10.1097/00000542-200405000-00025.
18. Pahakis MY, Kosky JR, Dull RO, Tarbell JM. The role of endothelial glycocalyx components in mechanotransduction of fluid shear stress. Biochem Biophys Res Commun. 2007;355(1):228–233. Doi: 10.1016/j.bbrc.2007.01.137.
19. Nieuwdorp M, van Haeften TW, Gouverneur MC, et al. Loss of endothelial glycocalyx during acute hyperglycemia coincides with endothelial dysfunction and coagulation activation in vivo. Diabetes. 2006;55(2):480–486. Doi: 10.2337/diabetes.55.02.06.db05-1103.
20. Lopez-Quintero SV, Cancel LM, Pierides A, et al. High glucose attenuates shear-induced changes in endothelial hydraulic conductivity by degrading the glycocalyx. PLoS One. 2013;8(11):e78954. Doi: 10.1371/journal.pone.0078954.
21. Reyes-Soffer G, Holleran S, Di Tullio MR, et al. Endothelial function in individuals with coronary artery disease with and without type 2 diabetes mellitus. Metabolism. 2010;59(9):1365–1371. Doi: 10.1016/j.metabol.2009.12.023.
22. Mulivor AW, Lipowsky HH. Inflammation- and ischemia-induced shedding of venular glycocalyx. Am J Physiol Heart Circ Physiol. 2004;286(5):H1672–H1680. Doi: 10.1152/ajpheart.00832.2003.
23. Bruegger D, Rehm M, Jacob M, et al. Exogenous nitric oxide requires an endothelial glycocalyx to prevent postischemic coronary vascular leak in guinea pig hearts. Crit Care. 2008;12(3):R73. Doi: 10.1186/cc6913.
24. Chappell D, Jacob M, Hofmann-Kiefer K, et al. Hydrocortisone preserves the vascular barrier by protecting the endothelial glycocalyx. Anesthesiology. 2007;107(5):776–784. Doi: 10.1097/01.anes.0000286984.39328.96.
25. Rehm M, Bruegger D, Christ F, et al. Shedding of the endothelial glycocalyx in patients undergoing major vascular surgery with global and regional ischemia. Circulation. 2007;116(17):1896–1906. Doi: 10.1161/CIRCULATIONAHA.106.684852.
26. Bruegger D, Rehm M, Abicht J, et al. Shedding of the endothelial glycocalyx during cardiac surgery: on-pump versus off-pump coronary artery bypass graft surgery. J Thorac Cardiovasc Surg. 2009;138(6):1445–1447. Doi: 10.1016/j.jtcvs.2008.07.063.
27. Lewis JC, Taylor RG, Jones ND, et al. Endothelial surface characteristics in pigeon coronary artery atherosclerosis. I. Cellular alterations during the initial stages of dietary cholesterol challenge. Lab Invest. 1982;46(2):123–138.
28. Vink H, Constantinescu AA, Spaan JA. Oxidized lipoproteins degrade the endothelial surface layer: implications for platelet-endothelial cell adhesion. Circulation. 2000;101(13):1500–1502. Doi: 10.1161/01.cir.101.13.1500.
29. van den Berg BM, Spaan JA, Rolf TM, Vink H. Atherogenic region and diet diminish glycocalyx dimension and increase intima-to-media ratios at murine carotid artery bifurcation. Am J Physiol Heart Circ Physiol. 2006;290(2):H915–H920. Doi:10.1152/ajpheart.00051.2005.
30. Marechal X, Favory R, Joulin O, et al. Endothelial glycocalyx damage during endotoxemia coincides with microcirculatory dysfunction and vascular oxidative stress. Shock. 2008;29(5):572–576. Doi: 10.1097/SHK.0b013e318157e926.
31. Kharabi Masouleh B, Ten Dam GB, Wild MK, et al. Role of the heparan sulfate proteoglycan syndecan-1 (CD138) in delayed-type hypersensitivity. J Immunol. 2009;182(8):4985–4993. Doi: 10.4049/jimmunol.0800574.
32. Ostrowski SR, Gaïni S, Pedersen C, Johansson PI. Sympathoadrenal activation and endothelial damage in patients with varying degrees of acute infectious disease: an observational study. J Crit Care. 2015;30(1):90–96. Doi:10.1016/ j.jcrc.2014.10.006.
33. Johansson PI, Stensballe J, Rasmussen LS, Ostrowski SR. A high admission syndecan-1 level, a marker of endothelial glycocalyx degradation, is associated with inflammation, protein C depletion, fibrinolysis, and increased mortality in trauma patients. Ann Surg. 2011;254(2):194–200.
34. Shirazi LF, Bissett J, Romeo F, Mehta JL. Role of inflammation in heart failure. Curr Atheroscler Rep. 2017;19(6):27. Doi: 10.1007/s11883-017-0660-3.
