Authors
Maytesyan D.A.1, 2, Mzokov H.T.1, Papoyan S.A.2, 3, 4, Khazamov Sh.A.1, Takhtarova M.R.2
1 Municipal Сlinical Hospital № 15 named O.M. Filatov, Moscow
2 Pirogov Russian National Research Medical University, Moscow
3 Municipal Сlinical Hospital named F.I. Inozemtsev, Moscow
4 Research Institute of Health Care Organization and Medical Management, Moscow
Abstract
In recent decades, endovascular surgery has been developing by leaps and bounds, this technique performs operations on almost all vascular basins of the body. However, despite all the advantages and effectiveness of endovascular procedures, these interventions are not without complications. One of the most common complications is distal embolism, which is a well-known, but little-studied complication. It is a significant problem that worsens the outcome of the intervention and increases the risk of serious complications, including acute arterial thrombosis and limb ischemia. Timely recognition and effective treatment of this complication is of great importance for preventing the development of ischemia and preserving the patient’s limb. However, there is currently no consensus on the best treatment for acute complications of distal embolism during endovascular interventions for peripheral artery diseases. In this article, we analyze our clinical experience in the detection, diagnosis and treatment of distal embolism. The assessment of risk factors, methods of prevention and tactics of treatment of these complications was carried out. The observations and data obtained emphasize the importance of early diagnosis of distal embolisms and allow us to develop recommendations for improving clinical practice. The article will be useful for both specialists in the field of angiosurgery and doctors of other specialties involved in the treatment of vascular diseases of the lower extremities.
Keywords: endovascular interventions on the arteries of the lower extremities, atherosclerosis of the arteries of the lower extremities, complications of endovascular surgery, distal embolization, stenting of the arteries of the extremities, angioplasty of the arteries of the extremities.
References
1. Karnabatidis D, Katsanos K, Kagadis GC, et al. Distal embolism during percutaneous revascularization of infra-aortic arterial occlusive disease: an underestimated phenomenon. J Endovasc Ther. 2006; 13(3): 269-280. doi: 10.1583/05-1771.1.
2. Ochoa Chaar CI, Shebl F, Sumpio B, et al. Distal embolization during lower extremity endovascular interventions. J Vasc Surg. 2017; 66(1): 143-150. doi: 10.1016/j.jvs.2017.01.032.
3. Allie DE. To PROTECT or not to PROTECT? In lower extremity angioplasty procedures, “Why Not?” is the question! J Endovasc Ther. 2008; 15(3): 277-282. doi: 10.1583/08-2397C.1.
4. Olin JW, Allie DE, Belkin M, et al. ACCF/AHA/ACR/SCAI/SIR/SVM/SVN/SVS 2010 performance measures for adults with peripheral artery disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Performance Measures, the American College of Radiology, the Society for Cardiac Angiography and Interventions, the Society for Interventional Radiology, the Society for Vascular Medicine, the Society for Vascular Nursing, and the Society for Vascular Surgery. J Vasc Nurs. 2011; 29(1): 23-60. doi:10.1016/j.jvn.2010.11.002.
5. Boc A, Blinc A, Boc V. Distal embolization during percutaneous revascularization of the lower extremity arteries. Vasa. 2020; 49(5): 389-394. doi: 10.1024/0301-1526/a000877.
6. Antithrombotic Trialists’ Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients [published correction appears in BMJ 2002; 324(7330): 141]. BMJ. 2002; 324(7329): 71-86. doi: 10.1136/bmj.324.7329.71.
7. CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee. Lancet. 1996; 348(9038): 1329-1339. doi: 10.1016/s0140-6736(96)09457-3.
8. Almeida SO, Budoff M. Effect of statins on atherosclerotic plaque. Trends Cardiovasc Med. 2019; 29(8): 451-455. doi:10.1016/j.tcm.2019.01.001.
9. Heart Protection Study Collaborative Group. Randomized trial of the effects of cholesterol-lowering with simvastatin on peripheral vascular and other major vascular outcomes in 20,536 people with peripheral arterial disease and other high-risk conditions. J Vasc Surg. 2007; 45(4): 645-654. doi: 10.1016/j.jvs.2006.12.054.
10. Kumbhani DJ, Steg PG, Cannon CP, et al. Statin therapy and long-term adverse limb outcomes in patients with peripheral artery disease: insights from the REACH registry. Eur Heart J. 2014; 35(41): 2864-2872. doi: 10.1093/eurheartj/ehu080.
11. Zil-E-Ali A, Medina D, Orozco D, et al. Preoperative Statin Use is Associated With Lower Incidence of Limb Loss After Lower Extremity Endovascular Interventions. Am Surg. 2022; 88(11): 2719-2729. doi: 10.1177/00031348211068000.
12. Osipova OS, Gostev AA, Karpenko AA. Clinical significance of distal embolism in intravascular recanalization of the superficial femoral artery. Cardiovascular Therapy and Prevention. 2023; 22(6): 3512. (In Russ). doi: 10.15829/1728-8800-2023-3512.