Authors
Yakovlev R.A.1, Gorbunova N.Yu.1, 2, Voskresenskaya A.A.1, 2, Pozdeyeva N.A.1, 2
1 Cheboksary branch of the S. Fyodorov Eye Microsurgery Federal State Institution, Cheboksary
2 State Autonomous Continuing Education Institution «Institute for Advanced Medical Training» of the Ministry of Health of the Chuvash Republic, Cheboksary
Abstract
Relevance: сurrently, micropulse transscleral cyclophotocoagulation is widely used for the treatment of refractory glaucoma. It has a high safety profile and can be applied to eyes with high visual potential. Continuous-wave cyclophotocoagulation has a more pronounced hypotensive effect; however, it is accompanied by a significant number of complications. During transscleral cyclophotocoagulation, it is suggested to use a standard position for the sensor, though the position of the ciliary processes may vary.
Purpose: to analyze the effectiveness and safety of the combined cyclophotocoagulation technique using transillumination.
Materials and Methods: the study included 22 patients (22 eyes) who underwent combined cyclophotocoagulation with transillumination. The observation period was 6 months, with control examinations conducted at 1, 3, and 6 months. At each visit, refractokeratometry, visual acuity assessment, ultrasound examination (B-scan), tonometry using the Maklakov method were performed. There was one case of postoperative uveitis in the form of iridocyclitis.
Results: after six months, intraocular pressure decreased by 45% from the baseline level-from 35.5 (34–38.5) mm Hg to 20 (20–21) mm Hg. The number of hypotensive therapy drops was also reduced-from 7 (5.75–7) to 4 (3.25–4) drops per day.
Conclusion: combined cyclophotocoagulation with transscleral transillumination demonstrated a stable hypotensive effect over 6 months, with no significant complications such as prolonged hypotony, phthisis bulbi, or persistent refractory uveitis, which are commonly seen with continuous-wave cyclophotocoagulation. Thus, this technique may become an effective alternative to standard methods of cyclophotocoagulation.
Keywords: glaucoma, cyclophotocoagulation, transillumination.
References
1. Gaasterland DE, Pollack IP. Initial experience with a new method of laser transscleral cyclophotocoagulation for ciliary ablation in severe glaucoma. Trans Am Ophthalmol Soc. 1992;90:225-243; discussion 243-246.
2. Tan AM, Chockalingam M, Aquino MC, Lim ZIL, See JLS, Chew PT. Micropulse transscleral diode laser cyclophotocoagulation in the treatment of refractory glaucoma. Clin Exp Ophthalmol. 2010;38(3):266-272. doi:10.1111/j.1442-9071.2010.02238.x
3. Aquino MCD, Barton K, Tan AMWT, et al. Micropulse versus continuous wave transscleral diode cyclophotocoagulation in refractory glaucoma: a randomized exploratory study. Clin Exp Ophthalmol. 2015;43(1):40-46. doi:10.1111/ceo.12360
4. Kelada M, Normando EM, Cordeiro FM, et al. Cyclodiode vs micropulse transscleral laser treatment. Eye (Lond). 2024;38(8):1477-1484. doi:10.1038/s41433-024-02929-1
5. Lg W, Hq J, Cv J, et al. Combined Technique for the Application of Micropulse Cyclophotocoagulation in Patients with Uncontrolled Glaucoma: Cyclo Mix. Journal of current glaucoma practice. 2020;14(3). doi:10.5005/jp-journals-10078-1289
6. Agrawal P, Martin KR. Ciliary body position variability in glaucoma patients assessed by scleral transillumination. Eye (Lond). 2008;22(12):1499-1503. doi:10.1038/eye.2008.79
7. Sharma A, Ali A, Henderson RH, Patel CK, VandenHoven C, Lam WC. Accuracy of scleral transillumination techniques to identify infant ciliary body for sclerostomy and intravitreal injections. Clin Exp Ophthalmol. 2019;47 (4):478-483. doi:10.1111/ceo.13442
8. Duerr ER, Sayed MS, Moster S, et al. Transscleral Diode Laser Cyclophotocoagulation: A Comparison of Slow Coagulation and Standard Coagulation Techniques. Ophthalmol Glaucoma. 2018;1(2):115-122. doi:10.1016/j.ogla.2018.08.007
9. Grippo TM, Töteberg-Harms M, Giovingo M, et al. Evidence-Based Consensus Guidelines Series for MicroPulse Transscleral Laser Therapy - Surgical Technique, Post-Operative Care, Expected Outcomes and Retreatment/Enhancements. Clin Ophthalmol. 2023;17:71-83. doi:10.2147/OPTH.S389198
10. Shah P, Bhakta A, Vanner EA, Kishor KS, Greenfield DS, Maharaj ASR. Safety and Efficacy of Diode Laser Transscleral Cyclophotocoagulation in Eyes With Good Visual Acuity. J Glaucoma. 2018;27(10):874-879. doi:10.1097/IJG.0000000000001057.