Authors
Fedzianin S.D.1, Stavchikov E.L.1, 2, Kovalenko A.A.1, Matusevich E.A.3, Shilin V.E.1
1 Vitebsk State Order of Friendship of Peoples Medical University, Vitebsk, Belarus
2 Mogilev Regional Clinical Hospital, Mogilev, Belarus
3 Vitebsk Regional Clinical Hospital, Vitebsk, Belarus
Abstract
Backgraund: the treatment of patients with wound defects of soft tissues is a difficult task for the healthcare system. Despite the variety of methods, it is not always possible to achieve positive results. The development of new technologies aimed at stimulating of regeneration can help improve the results of skin plastic in the complex treatment of wounds.
Aims: to study the clinical efficacy of the wounds plastics using autologous red bone marrow aspirates.
Materials and methods: a prospective simple controlled randomized clinical trial was conducted on two parallel groups of patients.
The study involved 84 patients with wounds that arose after surgical treatment of abscesses and phlegmons, surgical site infections and injuries. The main group consisted of 42 patients who used the technique of the wounds plastics using autologous red bone marrow aspirates. Indication for use of the method – wounds with the signs of chronicity of wound healing. The area of wounds defects was 24 (12; 32,5) cm2. The comparison group consisted of 42 patients who were treated using traditional methods. The area of wounds defects was 23,8 (11,98; 31,6) cm2. The planimetry was performed using ImageJ software. Statistical data processing was performed using Microsoft Excel 2018, Statistica 7.0 and IBM SPSS Statistics 22 programs. The differences between the groups were considered significant at p<0,05.
Results: among 42 patients in the main group, in 33 (78,57%) wounds healed, in 6 (14,29%) – partial lysis was noted, in 3 (7,14%) – lysis of the skin flap. Among 42 patients in the comparison group, wound healing was observed in the 26 (61,9%) patients, partial flap lysis – in the 7 (16,67%) patients, and lysis – in 9 (21,43%) (p<0,05).
Conclusion: the wounds plastics using autologous red bone marrow aspirates is characterized by a fairly high clinical efficacy. This approach significantly improved the results of autodermoplasty by 16,67%.
Keywords: red bone marrow, wound, plastic.
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