Authors
Gulov M.K., Nurzoda Z.M., Ruziboyzoda K.R.
Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
Abstract
Aim. To study the severity of changes in indicators of endotoxemia and endothelial dysfunction in blood serum in patients with chronic colonic stasis.
Materials and methods. The results of a comprehensive study of indicators of endotoxemia and endothelial dysfunction in the blood serum of 92 patients with various stages of chronic colonic stasis were analyzed. Patients with chronic colonic stasis were divided into 3 groups according to the stage of the disease. There were 31 (33.7%) patients with chronic colonic stasis in the compensation stage, 33 (35.9%) patients with subcompensation, and 28 (30.4%) patients with decompensated chronic colonic stasis.
Results. As the duration and progression of the severity of colostasis, significant changes are observed in the indicators of endogenous intoxication with an increase in the leukocyte index of intoxication, molecules of average mass, erythrocyte sedimentation rate, creatinine and C-reactive protein, and a decrease in the level of prothrombin index and fibrinogen, in particular, in the sub- and decompensation. It also contributed to an increase in the number of markers of endothelial dysfunction, such as the level of endothelin-1, nitric oxide, and a decrease in thrombomodulin.
Conclusion. Thus, a comprehensive study of patients with chronic colonic stasis made it possible to identify pronounced changes in the indicators of endogenous intoxication and endothelial dysfunction in the blood serum, which directly correlate with the duration and stage of colostasis.
Keywords: chronic colonic stasis, stages of colostasis, endotoxicosis, endothelial dysfunction, blood serum.
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