Authors
Doktorova T.A. 1, 2, Suetov A.A.1, 3, Bojko E.V.1, 2, Sosnovskij S.V.1
1 St. Petersburg Branch S. Fyodorov Eye Microsurgery Federal State Institution St. Petersburg
2 Department of Ophthalmology North-Western State Medical University named after I.I. Mechnikov St. Petersburg
3 State Scientific Research Test Institute of Military Medicine, St. Petersburg
Abstract
Background. Different optical coherence tomography angiography (OCT-A) devices use various vascular signal visualization algorithms. Comparability of perfusion parameters in the monitoring of macular diseases, including full-thickness macular hole (FTMH) remains poorly understood.
Aim. To study the relationship between quantitative indicators of macular perfusion in FTMH, recorded using various OCT-A devices.
Materials and methods. A prospective study including 25 patients (25 eyes) with idiopathic FTMH stage 4 according to D. Gass. OCT-A scanning was performed on Solix (Optovue, USA), Cirrus HD OCT (Carl Zeiss Meditec, USA) and DRI OCT Triton plus (Topcon, Japan) tomographs using a 6x6 and 3x3 mm protocol. The area and perimeter of the foveal avascular zone (FAZ), and the vessel density in the superficial capillary plexus (SCP) in the foveal and perifovea zones, automatically calculated by the software of the devices (AngioVueTM, AngioplexTM and SS OCT AngioTM) were analyzed.
Results. The FAZ area didn’t differ significantly and when measured on Solix, Cirrus HD OCT and DRI OCT Triton plus, respectively, were 0.28 (0.24; 0.38) mm2, 0.32 (0.26; 0.38) mm2 and 0.35 (0.26;0.41) mm2. The FAZ perimeter was significantly smaller when measured on Solix (2.34 (2.05;2.53) mm, p = 0.01). A significant correlation was revealed for the area and perimeter of the FAZ measured on different OCT-A devices (R>0.9 and R>0.7, respectively, p<0.01). The SCP vessel density in the fovea and perifovea zones was significantly different between all OCT-A devices, while the indicators correlated between all devices only in the fovea zone (R>0.67, p<0.05).
Conclusion. Performing OCT-A in eyes with FTMH using the Solix, Cirrus HD OCT and DRI OCT Triton plus devices, the greatest agreement in values was found for the area and perimeter of the FAZ. Indicators of SCP vessel density in the retina surrounding the hole, when measured on different devices, differ significantly and do not agree with each other.
Keywords: full-thickness macular hole, OCT, optical coherence tomography-angiography, superficial capillary plexus, foveal avascular zone, FAZ.
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