DOI: 10.25881/20728255_2022_17_1_54

Authors

Pronin A.G., Sivokhina N.Y., Rakhmatullina A.R., Glukhov D.K.

Pirogov National Medical and Surgical Center, Moscow

Abstract

The establishment of prognostic criteria for the outcome of pulmonary embolism is an important aspect for creating an algorithm for optimal tactics of treatment of patients.

Aims: to determine the relationship of prognostic criteria of pulmonary embolism in order to establish the most significant of them.

Materials and methods: the study included 428 patients with pulmonary embolism, of whom 21 died, and 50 developed chronic thromboembolic pulmonary hypertension in the long-term follow-up period. An analysis was carried out to establish the most significant criteria for adverse outcomes and their relationship.

Results: the significance of adverse outcomes of pulmonary embolism for criteria such as the presence of hypotension with a decrease in systolic blood pressure of less than 90 mm Hg, an increase in the plasma concentration of troponin, echocardiography signs of overload of the right ventricle was confirmed. At the same time, the presence of right ventricular overload criteria in echocardiography is more significant than an increase in the level of plasma troponin concentration, the most common of them are an increase in the ratio of the size of the right ventricle to the left more than 0.9 and an increase in systolic pressure in the pulmonary artery more than 50 mm Hg.

Conclusions: the most significant echocardiography prognostic criterion in patients with pulmonary embolism is an increase in the ratio of the size of the right ventricle to the left more than 0.9.

Keywords: pulmonary embolism, hemodynamics, outcomes of the disease, echocardiography, troponin.

References

1. Kovalyova GV, Korolyova LYu, Amineva NV, et all. Difficulties in differential diagnosis of pulmonary embolism in a therapeutic clinic. Rupture of esophageal diverticulum simulating a pulmonary thromboembolism (a case from practice). Medicinskij Al’manah. 2018; 1: 98-100. (In Russ). doi:10.21145/2499-9954–2018–1–98–100.

2. Konstantinides SV, et al. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS). The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC). European Heart Journal. 2020; 41: 543-603. doi: 10.1093/eurheartj/ehz405.

3. Becattini C, Agnelli G. Acute treatment of venous thromboembolism. Blood. 2020; 5: 305-316. doi: 10.1182/blood.2019001881.

4. Bokarev IN, Popov LV, editors. Venous thromboembolism and pulmonary embolism. Moscow: MIA; 2013: 512. (In Russ).

5. Ovchinnikov YuV, Linchak RM, Zelenov MV, et al. Successfulthrombolytic therapy in female patient with massive pulmonary embolism in early post-operativeperiod. Russian military medical journal. 2017; 9: 74-76 (In Russ). doi: 10.17816/RMMJ73486.

6. Shlyakhto EV. Cardiology. National leadership. Short edition. Moscow: GEOTAR-Media. 2019: 816. (In Russ).

7. Zatevakhin II, Kiriyenko AI, Stoiko YuM, et al. Diagnostics and Treatment of Chronic Venous Disease: Guidelines of Russian Phlebological Association. Flebologiya. 2018; 12(3): 146-240. (In Russ). doi:10.17116/flebo20187031146.

8. Delmas C, Aissaoui N, Meneveau N, et al. Reperfusion therapies in pulmonary embolism-state of the art and expert opinion: A position paper from the “Unite de Soins Intensifs de Cardiologie” group of the French Society of Cardiology. Arch Cardiovasc Dis. 2020; 11: 749-759. doi: 10.1016/j.acvd.2020.06.002.

9. Belyalov FI. Clinical guidelines for cardiology. 2017: 288. (In Russ).

10. Barco S, Mahmudpur SH, Plunketka B, et al. Prognostic value of right ventricular dysfunction or elevated cardiac biomarkers in patients with low-risk pulmonary embolism: a systematic review and meta-analysis. Eur Heart J. 2019; 11: 902-910. doi: 10.1093/eurheartj/ehy873.

11. Gilyarov MY, Konstantinova EV. How new approaches to the treatment of pulmonary embolism affect the outcome of the disease? Medical Council. 2017; 7: 48-55. (In Russ). doi: 10.21518/2079–701X–2017–7–48–55.

12. Neklyudova GV, Naumenko ZhK. Ultrasound diagnostic opportunities in pulmonology. Russian Pulmonology. 2017; 27(2): 283-290. (In Russ). doi: 10.18093/0869 0189 2017 27 2 283 290.

13. Panchenko EP, Balahonova TV, Danilov NM, et al. Diagnosis and Management of pulmonary embolism: Eurasian Association of Cardiology (EAC) Clinical Practice Guidelines (2021). Eurasian heart journal. 2021; (1): 44-77 (In Russ). doi:10.38109/2225-1685-2021-1-44-77.

14. Dzhioeva ON, Orlov DO, Nikitin IG. Echocardiography in acute cardiovascular care. Part 2. Cardiac and lung ultrasound examination. Complex Issues of Cardiovascular Diseases. 2020; 9(3): 49-58. (In Russ). doi: 10.17802/2306–1278–2020–9–3–49–58.

15. Kochmareva ЕА, Kokorin VА, Volkova АL, et al. Predictors of short term outcomes in high and moderate risk pulmonary thromboembolism. Russian Journal of Cardiology. 2017; 9: 7-12. (In Russ). doi: 10.15829/1560–4071–2017–9–7–12.

16. Chernyavskiy MA, Kudaev YA, Chernov AV, et al. Endovascular treatment of acute pulmonary embolism. Translational Medicine. 2018; 5(4): 5-11. (In Russ). doi:10.18705/2311-4495-2018-5-4-5-11.

17. D’Armini AM. Diagnostic advances and opportunities in chronic thromboembolic pulmonary hypertension: review. Eur. Respir. Rev. 2015; 24: 253-262. doi: 10.1183/16000617.00000915.

18. Dzhordzhikiya RK, Vagizov II, Stekol’shchikova NYu, et al. Topical issues of diagnosis and treatment of acute pulmonary embolism. Medicinskij Al’manah. 2015; 38(3): 37-39. (In Russ).

19. Kochmareva ЕА, Kokorin VА, Volkova АL, et al. Modern possibilities of prediction of clinical course and outcome of pulmonary embolism. Medical news of north Caucasus. 2017; 9: 476-483. (In Russ). doi: 10.14300/mnnc.2017.12133.

For citation

Pronin A.G., Sivokhina N.Y., Rakhmatullina A.R., Glukhov D.K. Relationship of prognostic criteria of pulmonary embolism. Bulletin of Pirogov National Medical & Surgical Center. 2022;17(1):54-57. (In Russ.) https://doi.org/10.25881/20728255_2022_17_1_54