DOI: 10.25881/20728255_2022_17_1_23

Authors

Politova A.K., Bolomatov N.V., Bruslik S.V., Slabozhankina E.A., Sviridova T.I. Amelina Yu.L.

Pirogov National Medical and Surgical Center, Moscow

Abstract

Surgery for endovascular embolization of the uterine arteries (UAE) for uterine myoma has a number of disadvantages. Having analyzed the pathophysiology and complications of UAE, our research group proposed a technique for superselective embolization of uterine fibroids arteries. Considering the locality of embolization, we called this technique “sniper” technology for embolization of uterine fibroids (MM).

Purpose of the study. To evaluate the immediate results of superselective arterial embolization of vessels of myomatous nodes in uterine myoma.

Material and methods. The study included 132 patients with a diagnosis of MM, who underwent 133 operations. Age 42.8±5.7 (from 32 to 57 years old). All patients underwent embolization of arteries feeding the myomatous node of the MM using microcatheter technique. In order to assess the effectiveness of MM occlusion, transvaginal ultrasound with Doppler ultrasound was performed before the operation and the next day after the operation, before the patient was discharged and 14, 30 days after the operation.

Results. The following were used as arterial approaches for UAE: radial — 75 (56.3%); shoulder — 52 (39.0%); femoral approach — 5 (3.7%). In 19 (14.2%) patients, UAE of only one artery was performed. The absence of blood flow in the myomatous nodes with its contraction in the uterine and ovarian arteries was in 132 (100%) patients.

Conclusions. 1. Method of arterial superselective embolization of myomatous nodes of the uterus is an effective and safe method of treatment. 2. The method of superselective arterial embolization of myomatous nodes of the uterus needs additional research.

Keywords: uterine fibroids, fibroids, superselective, embolization, sniper, polyvinyl alcohol, microspheres, microcatheter.

References

1. Adamyan LV, Andreeva EN, Artymuk NV, et al. «Letter of the Ministry of Health of Russia dated 02.10.2015 N 15-4 / 10 / 2-5805 «On the direction of clinical recommendations of uterine fibroids: diagnosis, treatment and rehabilitation». (In Russ).

2. Heaston DK, Mineau DE, Brown BJ, et al. Transcatheter arterial embolization for the control of persistent massive puerperal hemorrhage after bilateral surgical hypogastric artery ligation. AJR Am J Roentgenol. 1979; 133: 152-154. doi:10.2214 / ajr.133.1.152.

3. Spies JS, Pelage JP. Uterine artery embolization and gynecologic embolotherapy. Philadelphia: Lippincott Williams & Wilkins; 2005; 3-18.

4. Ravina JH, Herbreteau D, Ciraru-Vigneron N, et al. Arterial embolization to treat uterine myomata. Lancet. 1995; 346: 671-672. doi: 10.1016 / s0140-6736 (95) 92282-2.

5. Goodwin SC, Vedantham S, McLucas B, et al. Preliminary experience with uterine artery embolization for uterine fibroids. J Vasc Interv Radiol. 1997; 8: 517-526. doi: 10,1016 / s1051-0443 (97) 70603-1.

6. Goodwin SC, Bonilla SM, Sacks D, et al. Reporting standards for uterine artery embolization for the treatment of uterine leiomyomata. J Vasc Interv Radiol. 2001; 12: 1011-1020. doi: 10.1016 / s1051-0443 (07) 61586-3.

7. Ravina J, Uterine fibroids. Embolization: state-of-the-art. Gynecol Obstet Fertil 2004; 32: 1057-63. Gynecol Obstet Fertil. 2005, 33: 363-364. doi: 10.1016/j.gyobfe.2005.04.004.

8. Said Izreig, Arash Fereydooni and Naiem Nassiri (June 21st 2019). Uterine Fibroid Embolization, Leiomyoma, Hassan Abduljabbar, IntechOpen. doi: 10.5772/intechopen.86937.

9. Ravina J, Uterine fibroids. Embolization: state-of-the-art. Gynecol Obstet Fertil 2004; 32: 1057-63. Gynecol Obstet Fertil. 2005, 33: 363-364.

10. Poujade O, Ceccaldi PF, Davitian C, et al. Uterine necrosis following pelvic arterial embolization for post-partum hemorrhage: Review of the literature. European Journal of Obstetrics & Gynecology and Reproductive Biology 2013, 170(2): 309-314. doi:10.1016/j.ejogrb.2013.07.016.

11. Mutiso SK, Oindi FM, Hacking N, et al. Uterine Necrosis after Uterine Artery Embolization for Symptomatic Fibroids. Case Rep Obstet Gynecol. 2018; 28: 2018:9621741. doi: 10.1155/2018/9621741.

12. Karlsen K, Hrobjartsson A, Korsholm M, et al. Fertility after uterine artery embolization of fibroids: a systematic review. Arch Gynecol Obstet. 2018; 297: 13-25. doi: 10.1007/s00404-017-4566-7.

13. Domenico LJr, Siskin GP. Uterine artery embolization and infertility. Tech Vasc Interv Radiol. 2006; 9: 7-11. doi: 10.1053/j.tvir.2006.08.003.

14. Dobrokhotova YuE, Kapranov SA, Bobrov BYu, et al. Embolization of the uterine arteries – postembolization syndrome. Russian Bulletin of Obstetrician- Gynecologist. 2005; 5(2): 44-49. (In Russ).

15. Hemingway A, Allison D. Complications of embolization: analysis of 410 procedures. Radiology. 1998; 166: 669-672.

16. Ganguli S, Faintuch S, Salazar GM, et al. Postembolization syndrome: changes in white blood cell counts immediately after uterine artery embolization. J Vasc Interv Radiol. 2008; 19: 443-445. doi: 10.1016/j.jvir. 2007.11.021. PMID: 18295706.

17. Bae SH, Kim MD, Kim GM, et al. Uterine Artery Embolization for Adenomyosis: Percentage of Necrosis Predicts Midterm Clinical Recurrence. J Vasc Interv Radiol. 2015; 26: 1290-6.e2. doi: 10.1016/j.jvir.2015.04.026.

18. Marret H, Cottier JP, Alonso AM, et al. Predictive factors for fibroids recurrence after uterine artery embolisation. BJOG. 2005; 112: 461-5. doi: 10.1111/j.1471-0528.2004.00487.x.

19. Bolomatov NV. Embolization materials – characteristics and basic concepts of use. M.: RANS, 2020. P.29. (In Russ).

20. Poujade O, Ceccaldi PF, Davitian C, et al. Uterine necrosis following pelvic arterial embolization for post-partum hemorrhage: Review of the literature. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2013, 170(2): 309-314. doi.org/10.1016/j.ejogrb.2013.07.016.

21. Mutiso SK, Oindi FM, Hacking N, et al. Uterine Necrosis after Uterine Artery Embolization for Symptomatic Fibroids. Case Rep Obstet Gynecol. 2018; 28: 2018:9621741. doi: 10.1155/2018/9621741.

22. Domenico LJr, Siskin GP. Uterine artery embolization and infertility. Tech Vasc Interv Radiol. 2006; 9: 7-11. doi: 10.1053/j.tvir.2006.08.003.

23. Bilhim T, Pisco JM, Duarte M, et al. Polyvinyl alcohol particle size for uterine artery embolization: a prospective randomized study of initial use of 350-500 μm particles versus initial use of 500-700 μm particles. J Vasc Interv Radiol. 2011; 22: 21-27. doi: 10.1016/j.jvir.2010.09.018. Epub 2010 Nov 24.

24. Ganguli S, Faintuch S, Salazar GM, et al. Postembolization syndrome: changes in white blood cell counts immediately after uterine artery embolization. J Vasc Interv Radiol. 2008; 19: 443-445. doi: 10.1016/j.jvir.2007.11.021. PMID: 18295706.

25. Szkodziak P, Pyra K, Szkodziak F, et al. The Lublin Protocol of the Uterine Arteries Embolization in the Treatment of Symptomatic Uterine Fibroids. J Vis Exp. 2020; 15: 163. doi: 10.3791/61530. PMID: 33016950.

26. Pancholy SB, Bernat I, Bertrand OF, et al. Prevention of radial artery occlusion after transradial catheterization: the PROPHET-II Randomized Trial. JACC Cardiovasc Interv. 2016; 9: 1992-1999.

27. Uhlemann M, Mo¨bius-Winkler S, Mende M, et al. The Leipzig prospective vascular ultrasound registry in radial artery catheterization: impact of sheath size on vascular complications. JACC Cardiovasc Interv. 2012; 5: 36-43.

28. Tarkhanov A, Bartal G, Druzhin S, et al. Bladder wall and surrounding tissue necrosis following bilateral superselective embolization of internal iliac artery branches due to uncontrollable haematuria related to bladder tumor: case report. CVIR Endovasc. 2018; 1: 34. doi: 10.1186/s42155-018-0043-z.

29. Matityahu A, Marmor M, Elson JK, et al. Acute complications of patients with pelvic fractures after pelvic angiographic embolization. Clin Orthop Relat Res. 2013; 471(9): 2906-2911. doi: 10.1007/s11999-013-3119-z.

30. Ali A, Nabi G, Swami S, Somani B. Bladder necrosis secondary to internal iliac artery embolization following pelvic fracture. Urol Ann. 2014; 6(2): 166-168. doi: 10.4103/0974-7796.130657.

For citation

Politova A.K., Bolomatov N.V., Bruslik S.V., Slabozhankina E.A., Sviridova T.I. Amelina Yu.L. Superselective embolization of arteries feeding myomatous nodes in the treatment of uterine fibroids. Bulletin of Pirogov National Medical & Surgical Center. 2022;17(1):23-27. (In Russ.) https://doi.org/10.25881/20728255_2022_17_1_23