Authors
Kluiko D.A., Korik V.E., Zhidkov S.A.
Military Medical Institute at the EE «Belarusian State Medical University», Minsk, Republic of Belarus
Abstract
Rationale: the clinical manifestations of postoperative abdominal fusion have recently been studied quite well, however, the pathophysiological aspects of the formation and the mechanisms of adhesion development have not yet been fully established.
The aim of the study, carried out on 35 guinea pigs, was to determine the effect of the gas environment in the abdominal cavity and in the inhaled air on the expression of the factor induced by hypoxia.
Results: the expression of the factor indicated by hypoxia (HIF-1α) is significantly influenced by hyperoxia, hypoxia in the abdominal cavity (decrease by 55% and increase by 187% from the control group, respectively), in the inhaled air (decrease by 54% and increase by 194 % of the control group, respectively), the effect of fibrin (by 245%), simulated partial (by 278%) and complete (by 248%) intestinal obstruction, increased intra-abdominal pressure (by 298%), (p<0.001), contributing to the adhesion process.
Conclusion: the registered changes indicate a significant effect of hypoxia on the oxygenation of the abdominal organs. The development of hypoxia in the peritoneum contributes to the production of coarse fibrous connective tissue and, as a consequence, the adhesive process in the abdominal cavity. Maintaining normoxia in the postoperative period in patients with abdominal pathology is one of the most important tasks in the treatment of surgical patients.
Keywords: adhesive disease, hypoxia, oximetry, immunohistochemistry.
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