Authors
Shevchenko Yu.L., Borshchev G.G.
National Medical and Surgical Center named after N.I. Pirogov, Moscow
Abstract
The purpose of the article is to evaluate effects of essential vitamins on angiogenesis and to determine their potential use as pro or anti-angiogenic agents vitamins A, B, C, D, E and K. Vitamin A: 13-cis-retinoic acid and acyclic retinoid inhibit angiogenesis, while trans-retinoic acid has a pro-angiogenic property. Vitamin B1 is a proangiogenic substance. Vitamin B2 inhibits angiogenesis by reducing tyrosine phosphorylation. Vitamin B3 is a proangiogenic substance. Vitamin B6 suppresses the proliferation of endothelial cells and inhibits DNA polymerase, acting as an anti-angiogenic substance. Vitamin B9 reduces the synthesis of DNA and the proliferation of endothelial cells. Vitamin B12 is a proangiogenic vitamin. Vitamin C exhibits anti-angiogenic properties by inhibiting the formation of NO. Vitamin D acts as an anti-angiogenic substance by inducing the cell cycle and apoptosis of vascular and tumor cells. Vitamin E is an anti-angiogenic substance. It inhibits both proliferation and the formation of tubules from endothelial cells. Vitamin K acts as an anti-angiogenic substance through a K-dependent glycoprotein, inhibiting VEGF-R2-dependent vascularization.
Keywords: Angiogenesis, Regeneration, Vitamins A, B, C, D, E, K.
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