Authors
Khokhlov A.L., Rybachkov V.V., Bereznyak N.V.
Yaroslavl State Medical University, Yaroslavl
Abstract
The frequency of two CARD15 / NOD2 polymorphic variants (Gly908Arg, Leu3020insC) was studied in 40 patients with Crohn’s disease. All patients were admitted to the surgical departmentaccording to emergency indications. The diagnosis of Crohn’s disease was based on clinical data, ultrasound, visual assessment of the pathological process during the operation and histological examination of the surgical material. Studies were conducted in periods from 1 to 10 years from the date of discharge from the hospital. In the studied group, polymorphisms of the CARD15 / NOD2 were encountered with a frequency of 35%. The polymorphic variant Leu3020insC was found in 30% of patients, Gly908Arg was identified in 2.5% of patients, both polymorphic variants were identified in 2,5% of patients. The polymorphic variant Leu3020insC is associated with the localization of the pathological focus and is dominant in inflammation in the area of the ileocecalzone.
Keywords: Crohn’s disease, clinic, polymorphic variants of CARD15/ NOD2.
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