Authors
Puchkova O.S.1, Sinicyn V.E.2, Bogomazova S.Yu.3, Mershina E.A.2, Shirokij V.P.3, Bazhenova D.A.2, Nenajdenko E.V.2
1 Haddassah Medical Skolkovo, Moscow
2 FFM Lomonosov Moscow State University, Moscow
3 Federal Center of Medicine and Rehabilitation, Moscow
Abstract
To identify the presence of a correlation between the size, histology subtype of breast cancer and the tumor grade. In this study, 169 patients. All patients underwent a core biopsy with subsequent histological examination, and were divided into 2 groups. The first group consisted of 57 women (33.7%) with tumors arising in the terminal ductal-lobular unit - acinar adenocarcinoma (AAB) unifocal and multifocal forms, and the second group - 112 women (66.3%) with types of ductal adenocarcinoma in situ (in situ DAB) and ductal adenocarcinoma in situ associated with the acinar form of breast cancer (DAB + AAB). Evaluation of the breast density was made using ACR 2013 classification. The tumor size was measured on mammography and postoperative histology. The result of our study suggests the size of breast cancer of acinar origin do not associated with the component in situ, which accounts for 75% of the detected cancers in mammography, correlates with the degree of malignancy - the larger the tumor size, the higher the degree of malignancy, which confirms the data on the possible dedifferentiation of tumor cells during its growth. The degree of malignancy of breast cancer is one of the important predictors of long-term prognosis of treatment. Thus, the tumor size determined by mammography can be an independent prognostic factor already at the stage of diagnosis. Conclusions. The size of the breast cancer of acinar origin, determined at the time of diagnosis on mammography, correlates with the tumor Grade and can be an independent prognostic factor of the long-term patient outcome.
Keywords: breast cancer, mammography, long-term outcome, tumor grade.
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