Authors
Mazayshvili K.V., Agalarov R.M., Gustelev Yu.A.
Surgut State University, Surgut
Abstract
Endovenous laser obliteration (EVLO) has been routinely performed in all developed countries. In accordance with the law of large numbers, complications with a low probability began to be detected. Patient N., female, 38 years old, complained of a pain with redness of the skin in the projection of a varicose vein of the right leg. During ultrasound angioscanning, a thrombus was determined in the inflow of the right superior lower leg. The patient was prescribed anticogulant and compression therapy. The next day, against the background of anticoagulation, an EVLO GSV was performed, and day later, deep vein thrombosis of this limb arose. With a more thorough medical history taking, the patient indicated that she took vitamin C at 2 grams per day for 2 months. The review of the literatureprovides an attempt to show a previously obscure problem: the risk of thrombosis with large doses of vitamin C.
Keywords: endovenous laser ablation, complications, deep vein thrombosis, vitamin C.
References
1. Bjelakovic G. Nikolova LL, Gluud RG, et al. Antioxidant supplements for prevention of mortality in healthy participants and patients with various. Cochrane Database Syst. Rev. 2012;3:170- 176.
2. Bronstein AC. 2009 annual report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 27th annual. Clin. Toxicol. 2010;48(10):979–1178.
3. Gurunath S. Assisted reproductive techniques in a patient with history of venous thromboembolism: A case report and review of literature. J. Hum. Reprod. Sci. 2018;11(2):193.
4. Hindriks GA. Ascorbic acid increases the thrombogenicity of cellular matrices. Thromb. Haemost. 1991;66(4):505–509.
5. Horrobin DF. D.V.T. after Vitamin C? Lancet. 1973;302(7824):314.
6. Kim K. High-dose vitamin C injection to cancer ptients may promote thrombosis through procoagulant activation of erythrocytes. Toxicol. Sci. 2015;147(2): 350–359.
7. Lee DH, Folsom AR, Harnack L, et al. Does supplemental vitamin C increase cardiovascular disease risk in women with diabetes. Am. J. Clin. Nutr.2004; 80 (5):1194–1200.
8. Parahuleva M.S. Vitamin C suppresses lipopolysaccharide-induced procoagulant response of human monocyte-derived macrophages. Eur. Rev. Med. Pharmacol. Sci. 2016;20(10):2174–2182.
9. Sattar A.Possible warfarin resistance due to interaction with ascorbic acid: Case report and literature review.Am. J. Heal. Pharm. 2013;70(9): 782–786.
10. Smith EC. Interaction of Ascorbic Acid and Warfarin. Jama.1972;221(10):1166.
11. Spittle CR. Vitamin C and deep-vein thrombosis. Lancet.1973;302(7822):199–201.
12. Taylor TV. Leucocyte ascorbate levels and postoperative deep venous thrombosis. Br. J. Surg. 1979;66(8):583–585.
13. Tousoulis D, Antoniades C, Tountas C,. et al. Vitamin C Affects Thrombosis. Fibrinolysis System and Reactive Hyperemia in Patients With Type 2 Diabetes and Coronary Artery Disease. Diabetes Care. 2003;26(10):2749–2753.
14. Zerweck C. Penile Mondor’s Syndrome after endovenous treatment of the great saphenous vein with 1470 nm diode laser. Phlebology. 2015;30(3):217–219.
15. Shapovalova EM. Hemostasis with excess and lack of vitamin C in the diet. Fundamentalnye issledovanya. 2008;3:93–94. (In Russ).