Protrombin complex concentrate in coagulopathy prevention and treatment

Chemodanov I.G., Shestakov E.A., Zhiburt E.B.

We studied the practice of using the concentrate of the prothrombin complex (PCC) in the Pirogov Center. In 2012–2018, 59 patients received PCC 71 times. It has been established that PCC is effective in preventing and correcting bleeding in patients with laboratory-proven deficiency of the prothrombin complex proteins (an increase in INR). The prophylactic administration of PCC ensured the absence of indications for transfusion of red blood cell, platelets and plasma in 67.9, 82.1 and 53.6% of patients, respectively. The effectiveness of the introduction of the PCC in men and women is no different. The reduction in INR is not different in the prophylactic and therapeutic use of PCC: 1.0±0.3 and 1.2±0.6, respectively.

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