Authors
Shlyapnikov S.A.1, 3, Naser N.R.1, 2, Batyrshin I.M.1, Borodina M.A.1, 2, Sklizkov D.S.1, Ostroumova Yu.S.1, Ryazanova E.P.1, 2
1 State Institution «Saint Petersburg Research Institute Of Emergency Medecine named after I.I. Djanelidze», Saint-Petersburg
2 North-Western State Medical University named after I.I. Mechnikov, St. Petersburg
3 S.M. Kirov Military Medical Academy, St. Petersburg, Russia
Abstract
The number of diseases and pathological conditions associated with medical care is steadily increasing. The development of complications of antibacterial therapy just belongs to this number. One of the most severe, life-threatening complications is the development of antibiotic-associated diarrhea associated with clostridial infection (Cl.difficile) — clostridial pseudomembranous colitis, in which the mortality rate is almost 100% in the case of not timely diagnosis and not adequate treatment. In the medical community, there is still a global underestimation of the prevalence of this pathology, the severity and consequences. There is a lack of knowledge in etiopathogenesis, in the diagnosis, treatment and prevention of such a dangerous complication as clostridial colitis associated with antibiotic therapy. There is a lack of understanding of the surgical component of the problem of treating antibiotic-associated pseudomembranous colitis associated with Cl.difficile.
Keywords: antibiotic-associated diarrhea, pseudomembranous colitis, Cl.difficile associated diarrhea, complications of antibacterial therapy, surgical treatment of Cl.difficile associated diarrhea.
References
1. McDonald LC, Gerding DN, Johnson S, et al. Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis. 2018;66(1):e1–e48. Doi: 10.1093/cid/cix1085.
2. Luft VM, Lapitsky AV. Assotsiirovannaya s antibiotikami diareya: diagnostika, lechenie i profilaktika. Uchebno-metodicheskoe posobie. St. Petersburg: Saint-Petersburg institute of emergency care n.a. I.I.Dzhanelidze; 2012. 48 р.
3. Sartelli M, Di Bella St, McFarland LV, et al. 2019 update of the WSES guidelines for management of Clostridioides (Clostridium) difficile infection in surgical patients. World J Emerg Surg. 2019;14:8. Doi: 10.1186/s13017-019-0228-3.
4. Shelygin YuА, Aleshkin VA, Sukhina MA, et al. Klinicheskie rekomendatsii po diagnostike, lecheniyu i profilaktike Clostridium difficile-assotsiirovannoi diarei. Klinicheskie rekomendatsii. Moscow; 2017. 51 p. [cited 2020.06.18].
5. Natsional'naya assotsiatsiya spetsialistov po kontrolyu infektsii, svyazannykh s okazaniem meditsinskoi pomoshchi. Clostridium difficile-assotsiirovannaya diareya. Federal'nye klinicheskie rekomendatsii. Moscow; 2017. 41 p. [cited 2020.06.18].
6. Skazyvaeva EV, Skalinskaya MI, Bakulin IG, et al. Update of Clinical Practice Guidelines for Clostridium difficile infection by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA): a brief overview of key points, criticisms and future trends. Experimental and Clinical Gastroenterology. 2019;(5):3–14. Doi: 10.31146/1682-8658-ecg-165-5-3-14.
7. Chyornenkaya TV. Pseudomembranous colitis: diagnosis, treatment and prevention. Neotlozhnaya meditsinskaya pomoshch'. Zhurnal im. N.V. Sklifosovskogo. 2016;(1):33–39.
8. Nemtsov LM. Pseudomembranous colitis as a multidisciplinary problem. Vestnik Vitebskogo gosudarstvennogo meditsinskogo universiteta. 2014;13(3):6–19.
9. Ivashkin VT, Yushchuk ND, Mayev IV, et al. Diagnostics and treatment of Clostridium difficile-associated disease: Guidelines of the Russian gastroenterological association. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2016;26(5):56–65.
10. Terveer EM, van Beurden YH, Goorhuis A, et al. Faecal microbiota transplantation in clinical practice. Gut. 2017;67(1):196. Doi: 10.1136/gutjnl-2017-313909
11. Surawicz CM, Brandt LJ, Binion DG, et al. Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections. Am J Gastroenterol. 2013;108(4): 478–499. Doi: 10.1038/ajg.2013.4.
