Authors
Shirinbek O.1, Mnatsakanyan G.V.1, Odinokova S.N.2
1 SM-Clinic, Moscow
2 Sechenov First Moscow State Medical University, Moscow
Abstract
Cyanoacrylate adhesive closure (CAC) of varicose veins of the lower limbs has been in practical use for more than a decade. The main advantages of CAC are avoidance of tumescent anesthesia and post-interventional compression. In this clinical report we illustrate a case of glue ablation in a patient receiving life-long antithrombotic therapy (warfarin). The follow-up on 1, 3, 6 and 12 months post-procedure has shown occlusion of the target saphenous veins. However, following 36 months post intervention, recanalization of one of the two previously occluded veins has been detected.
Keywords: cyanoacrylate adhesive closure, glue ablation, varicose veins, antithrombotic therapy, warfarin, recanalization.
References
1. Lane TR, Pandey VA, Davies AH. Superficial venous disease treatment--is there still a role for open surgery in 2011? Acta Chir Belg. 2011; 111(3): 125-9. doi: 10.1080/00015458. 2011.11680722.
2. Bokerija LA, Mihajlichenko MV, Prjadko SI, Parikov MA, Kovalenko VI. Hirurgicheskoe lechenie bol’nyh s varikoznoj bolezn’ju nizhnih konechnostej. Jevoljucija problemy – proshloe i nastojashhee. Annaly hirurgii. 2014; №4: 5-12. (In Russ.)
3. Ontario Health (Quality). Nonthermal Endovenous Procedures for Varicose Veins: A Health Technology Assessment. Ont Health Technol Assess Ser. 2021; 21(8): 1-188.
4. Shirinbek O, Odinokova SN. Cyanoacrylate Adhesive Closure of Saphenous Veins. Journal of Venous Disorders. 2021; 15(4): 297‑303. (In Russ.) doi: 10.17116/flebo202115041297.
5. Shirinbek O. Handbook of a phlebologist surgeon. M.: GEOTAR-Media, 2024. 144 p. (In Russ.)
6. Shirinbek O, Mnatsakanyan GV, Odinokova SN. Cyanoacrylate adhesive Closure in the Real-World Practice: 2-Year results of varicose vein Treatment. Ambulatornaâ Hirurgiâ. 2022; 19(1): 132-139. (In Russ.) doi: 10.21518/1995-1477-2022-19-1-132-139.
7. Gao RD, Qian SY, Wang HH, Liu YS, Ren SY. Strategies and challenges in treatment of varicose veins and venous insufficiency. World Journal of Clinical Cases. 2022; 10(18): 5946-5956. doi: 10.12998/wjcc.v10.i18.5946.
8. Paravastu SCV, Horne M, Dodd PDF. Endovenous ablation therapy (laser or radiofrequency) or foam sclerotherapy versus conventional surgical repair for short saphenous varicose veins. Cochrane Library. 2016; 2016(11). doi: 10.1002/14651858.cd010878.pub2.
9. Shirinbek O, Mnatsakanyan GV, Odinokova SN. Adverse events and complications following cyanoacrylate adhesive closure of varicose veins. Angiologiâ I Sosudistaâ Hirurgiâ. 2023; 29(1): 59-66. (In Russ.) doi: 10.33029/ 1027-6661-2023-29-1-59-66.
10. Sharifi M, Mehdipour M, Bay C, Emrani F, Sharifi J. Effect of anticoagulation on endothermal ablation of the great saphenous vein. J Vasc Surg. 2011; 53(1): 147-9. doi: 10.1016/j.jvs. 2010.07.062.
11. Delaney CL, Russell DA, Iannos J, Spark JI. Is endovenous laser ablation possible while taking warfarin? Phlebology. 2012; 27(5): 231-4. doi: 10.1258/phleb.2011.011031.
12. Gabriel V, Jimenez JC, Alktaifi A, et al. Success of endovenous saphenous and perforator ablation in patients with symptomatic venous insufficiency receiving long-term warfarin therapy. Ann Vasc Surg. 2012; 26(5): 607-11. doi: 10.1016/j.avsg.2011.10.019.
13. Almeida JI, Javier JJ, Mackay EG, Bautista C, Proebstle T. Cyanoacrylate glue great saphenous vein ablation: preliminary 180-day follow-up of a first-in-man feasibility study of a no-compression-no-local-anesthesia technique. J Vasc Surg. 2012; 55: 297.
14. Elias S, Raines JK. Mechanochemical tumescentless endovenous ablation: final results of the initial clinical trial. Phlebology. 2011; 27(2): 67-72. doi: 10.1258/phleb.2011.010100.
15. Shirinbek O, Odinokova SN. Cyanoacrylate Adhesive Closure of Saphenous Veins. Journal of Venous Disorders. 2021; 15(4): 297‑303. (In Russ.) doi: 10.17116/flebo202115041297.
16. SHirinbek O. Kleevaya obliteraciya magistral’nyh podkozhnyh ven: rukovodstvo dlya vrachej. M.: GEOTAR-Media, 2022. (In Russ.) doi: 10.33029/9704-7103-6-KOV-2022-1-48.
17. Shirinbek O. Cyanoacrylate adhesive closure of refluxing saphenous veins. M.: GEOTAR-Media, 2023. doi: 10.33029/9704-7103-6-KOV-2022-1-48.
18. Dimech AP, Cassar K. Efficacy of Cyanoacrylate Glue Ablation of Primary Truncal Varicose Veins Compared to Existing Endovenous Techniques: A Systematic Review of the Literature. Surg J (N Y). 2020; 6(2): 77-86. doi: 10.1055/s-0040-1708866.
19. Pappas JN, Pappas PJ, Lakhanpal S, Kennedy R, Soto T. Natural history and role of anticoagulation in the management of endovenous glue-induced thrombus. J Vasc Surg Venous Lymphat Disord. 2023; 11(5): 938-945. doi:.1016/j.jvsv.2023.03.021.
20. Cho S, Gibson K, Lee SH, Kim SY, Joh JH. Incidence, classification, and risk factors of endovenous glue-induced thrombosis after cyanoacrylate closure of the incompetent saphenous vein. J Vasc Surg Venous Lymphat Disord. 2020; 8(6): 991-998. doi: 10.1016/j. jvsv.2020.01.009.
21. Sermsathanasawadi N, Pruekprasert K, Prapassaro T, et al. Thrombus extension after cyanoacrylate closure of incompetent saphenous veins. Int Angiol. 2022; 41(2): 143-148. doi: 10.23736/S0392-9590.22.04768-X.
22. Lane TR, Kelleher D, Moore HM, Franklin IJ, Davies AH. Cyanoacrylate glue for the treatment of great saphenous vein incompetence in the anticoagulated patient. J Vasc Surg Venous Lymphat Disord. 2013; 1(3): 298-300. doi: 10.1016/j.jvsv.2012.09.007.
