DOI: 10.25881/20728255_2024_19_3_153

Authors

Gamzaev M.G.1, Buldakov I.A.2, Kozlova M.A.1, Romanova D.A.3

1 The Moscow Research and Clinical Center for Tuberculosis Control, Moscow

2 S.N. Fedorov NMRC «MNTK «Eye microsurgery», Moscow

3 Pirogov Russian National Research Medical University, Moscow

Abstract

Intraocular tuberculosis is a great mystifier of various forms of uveitis, and it should be put in the first row in the differential diagnosis of any type of intraocular inflammation, as well as clearly differentiate it from other etiologies of choroidal lesions, which presents certain difficulties due to the diversity, mosaic, and often atypical clinic of the tuberculosis process. The article presents a clinical observation of tuberculous uveitis in a 61-year-old patient D., which was well stopped by non-specific anti-inflammatory therapy and antibacterial drugs. When conducting and evaluating the results of additional studies, such as computed tomography of the chest and a highly specific TSPOT.TB test, the patient was suspected to have a latent tuberculosis infection in the patient. As a result, a test with recombinant tuberculosis allergen (ATR) was performed, as a result of which the authors received a pronounced focal reaction from the eye. Thus, for the first time in the world scientific community, a clinical picture of a pronounced reaction of the eye to an ATR test is presented, since at the moment there is no information among the available sources of domestic and foreign literature that describes the same reaction to an ATR test as in the presented clinical example. The authors note that the eccentricity of the course of tuberculosis of the visual analyzer obliges the doctor to correctly collect an anamnesis, choose current diagnostic methods, correctly evaluate their results and evaluate the effectiveness of anti-tuberculosis therapy.

Keywords: ocular tuberculosis, ATP test, uveitis, anti-tuberculosis therapy.

References

1. Global Tuberculosis Report. 2020. WHO.

2. Syunyakova DA. Features of the epidemiology of tuberculosis in the world and in Russia in the period 2015-2020. Analytical survey. Social’nye aspekty zdorov’a naselenia. 2021; 67(3): 11. (In Russ.) doi: 10.21045/2071-5021-2021-67-3-11.

3. Salil M, Remco PH, Derrick PS, Vishali G. Ocular Tuberculosis in HIV-infected Individuals. Ocular Immunology and Inflammation. 2020. doi: 10.1080/09273948.2020.1776882.

4. Abdisamadov А, Tursunov О. Ocular tuberculosis epidemiology, clinic features and diagnosis: A brief review. Tuberculosis (Edinb). 2020; 124: 101963, doi: 10.1016/j.tube.2020.101963.

5. Luca C, Carl PH, Raffaella A, Carlo S, Luigi B. Tuberculous uveitis, a resurgent and underdiagnosed disease. Int Ophthalmol. 2009; 29(2): 67-74. doi: 10.1007/s10792-007-9071-8.

6. Faiz IS. Ocular tuberculosis: current perspectives. Clin Ophthalmol. 2015; 9: 2223-7. doi: 10.2147/OPTH.S65254.

7. Trad S, Saadoun D, Errera MH, Abad S, et al. Rev Med Interne. Ocular Tuberculosis. 2018; 39(9): 755-764. doi: 10.1016/j.revmed.2018.05.003.

8. Ang M, Wong W, Ngan CC, Chee SP. Interferon-gamma release assay as a diagnostic test for tuberculosis-associated uveitis. Eye. 2012; 26(5): 658-665.

9. Llorenç V, González-Martin J, Keller J, et al. Indirect supportive evidence for diagnosis of tuberculosis-related uveitis: from the tuberculin skin test to the new interferon gamma release assays. Acta Ophthalmol. 2013; 91(2): e99-e107. doi: 10.1111/j.1755-3768.2012.02564.x.

For citation

Gamzaev M.G., Buldakov I.A., Kozlova M.A., Romanova D.A. An individual approach to the diagnosis of uveitis of tuberculous etiology: from theory to practice. Bulletin of Pirogov National Medical & Surgical Center. 2024;19(3):153-155. (In Russ.) https://doi.org/10.25881/20728255_2024_19_3_153