DOI: 10.25881/20728255_2023_18_4_36

Authors

Khanevich M.D.1, Perminova A.A.1, Manikhas G.M.2

1 St. Petersburg State Pediatric Medical University, St. Petersburg

2 Pavlov First Saint Petersburg State Medical University, St. Petersburg

Abstract

We present the results of pancreatic cancer cryodestruction when radical surgical intervention is not possible. The results of the study show that cryosurgery can be effective in improving the duration and quality of life in inoperable patients with locally advanced pancreatic cancer. Using cryosurgery in some cases, it is possible to achieve the transfer of inoperable cancer to operable pancreatic cancer.

Keywords: cryodestruction, cryoapplicators, locally advanced pancreatic cancer, cryosurgery on a pancretic tumor, freezing of tumor tissue with liquid nitrogen.

References

1. Kaprin AD, Starinskij VV, Shaxzadova AO. Sostoyanie onkologicheskoj pomoshhi naseleniyu Rossii v 2021 godu. − M.: MNIOI im. P.A. Gercena, 2022. 239 р. (In Russ.)

2. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020; 70: 7-30.

3. National Cancer Institute. SEER Cancer Statistics Review, 1975–2018. National Cancer Institute; Bethesda, MD, USA: 2021.

4. Pancreatic Cancer. [URL] Accessed: 15 Nov. 2021.

5. Myers RS, Hammond WG, Ketcham AS. Cryosurgery of primate pancreas. Cancer. 1970; 25(2): 411-4. doi: 10.1002/1097-0142(197002)25:2<411::aid-cncr2820250220>3.0.co;2-7.

6. Patyutko YuI, Barkanov AI, Xolikov TK, et al. Kombinirovannoe lechenie mestno-rasprostranennogo raka podzheludochnoj zhelezy’ s ispol’zovaniem krioxirurgii. Voprosy’ Onkologii. 1991; 37: 695-700. (In Russ.)

7. Kovach SJ, Hendrickson RJ, Cappadona CR, et al. Cryoablation of unresectable pancreatic cancer. Surgery 2002; 131: 463-4.

8. Bhullar KS, Lagaron NO, McGowan EM et al. Kinase-targeted cancer therapies: Progress, challenges and future directions. Mol. Cancer. 2018; 17: 48. doi: 10.1186/s12943-018-0804-2.

9. Pecoraro C, Faggion B, Balboni B, et al. GSK3beta as a novel promising target to overcome chemoresistance in pancreatic cancer. Drug Resist. Updates. 2021; 58: 100779. doi: 10.1016/j.drup.2021.100779.

10. Xanevich MD, Manixas GM. Krioxirurgiya raka podzheludochnoj zhelezy’. SPb.: Agraf+, 2011. 228 р. (In Russ.)

11. Korpan NN, Hochwarter G, Sellner F. Cryoscience and cryomedicine: new mechanisms of biological tissue injury following low temperature exposure. Experimental study. Klinicheskaia Khirurgiia. 2009; 7-8: 80-5.

12. Niu L, Chen J, Yao F, et al. Percutaneous cryoablation for stage IV lung cancer: a retrospective analysis. Cryobiology. 2013; 67: 151-155.

13. Niu L, Mu F, Zhang C, et al. Cryotherapy protocols for metastatic breast cancer after failure of radical surgery. Cryobiology. 2013; 67: 17-22.

For citation

Khanevich M.D., Perminova A.A., Manikhas G.M. The use of cryodestruction of pancreatic cancer when it is impossible to perform radical surgery. Bulletin of Pirogov National Medical & Surgical Center. 2023;18(4):36-38. (In Russ.) https://doi.org/10.25881/20728255_2023_18_4_36