Authors
Sosnovskij S.V. 1, Bojko E.V.1, 2, Suetov A.A.1, 3, Doktorova T.A.1, 2, SHumova D.I.1, Petrosyan Yu.M.1
1 St. Petersburg Branch S. Fyodorov Eye Microsurgery Federal State Institution, St. Petersburg
2 Department of Ophthalmology Mechnikov North-West State Medical University, St. Petersburg
3 State Scientific Research Test Institute of Military Medicine, St. Petersburg
Abstract
Background. Nowadays we have limited information about the effective treatment for the scar stage of neovascular age-related macular degeneration.
Aim. To study of the functional effectiveness of retinal pigment epithelium autotranslocation in case of scarred neovascular age-related macular degeneration.
Materials and methods. The study included 21 patients with subretinal fibrosis associated with neovascular AMD that received the free pigment epithelium graft autotranslocation. Functional effectiveness was analyzed using best-corrected visual acuity dynamic in 13 patients with a follow-up period of at least 3 months after silicone removal.
Results. BCVA increased from 0.05±0.02 initially to 0.08±0.04 at the end of follow-up (p<0.05). Changes in BCVA were: deterioration – 3 patients, no changes – 1 patient, improvement – 9 patients.
Conclusion. Autotranslocation of the pigment epithelium can lead to a significant improvement in visual acuity in case of subretinal fibrosis assosiated with neovascular age-related macular degeneration.
Keywords: neovascular age-related macular degeneration, choroidal neovascularization, subretinal fibrosis, pigment epithelium transplantation.
References
1. Peyman G.A. A technique for retinal pigment epithelium transplantation for age-related macular degeneration secondary to extensive subfoveal scarring / G.A. Peyman, K.J. Blinder, C.L. Paris [et al.] // Ophthalmic Surg. – 1991. – Vol.22. – P.102–108.
2. Maaijwee K. Retinal pigment epithelium and choroid translocation in patients with exudative age-related macular degeneration: long-term results / K. Maaijwee, H. Heimann, T. Missotten [et al.] // Graefes Arch Clin Exp Ophthalmol. – 2007. – Vol.245(11). – P.1681-1689 [URL].
3. Parolini B. Long-term results of autologous retinal pigment epithelium and choroid transplantation for the treatment of exudative and atrophic maculopathies / B. Parolini, A. Di Salvatore, S.J. Pinackatt [et al.] // Retina. – 2020. – Vol. 40 (3). – P. 507–20. DOI: 10.1097 / IAE. 0000000000002429.
4. Caramoy A. Autologous translocation of choroid and retinal pigment epithelium in geographic atrophy: long-term functional and anatomical outcome / Caramoy A., Liakopoulos S., Menrath E., Kirchhof B. // Br J Ophthalmol. – 2010. – Vol. 94(8). – p. 1040-1044. doi: 10.1136/bjo.2009.161299.
5. van Zeeburg E. Visual acuity of 20/32, 13.5 years after a retinal pigment epithelium and choroid graft transplantation / van Zeeburg E., Maaijwee K., van Meurs J. // Am J Ophthalmol Case Rep. – 2018. Vol. 1:10. – p. 62-64. doi: 10.1016/j.ajoc.
