Authors
Kulko A.B.1, Fedorova N.I.2
1. Moscow Municipal Scientific and Practical Center for Tuberculosis Control of the Department of Health of Moscow, Moscow.
2. Federal State Public Institution «National Medical and Surgical Center named after N.I. Pirogov» of the Ministry of Healthcare of the Russian Federation.
Abstract
We evaluated and analyzed levels of susceptibility to modern antifungals for 12 causative agents of aspergillosis: Aspergillus flavipes, A. flavus, A. fumigatus, A. glaucus, A. nidulans, A. niger, A. ochraceus, A. oryzae, A. sydowii, A. terreus, A. ustus, A. versicolor. Determination of antimycotic susceptibility of 217 clinical strains of Aspergillus spp. carried out by the broth microdilution method with determination of MIC (μg/ml) (the «Sensititre» system). We established that causative agents of aspergillosis differed by levels of susceptibility to amphotericin B. We also observed high activity of voriconazole, itraconazole, and posaconazole against Aspergillus spp., except some strains of A. ustus (reduced susceptibility to azoles, testing before treatment is required), and several strains of A. nidulans and A. niger.
Keywords: pulmonary aspergillosis; susceptibility of fungi from genus Aspergillus to antimycotics; the «Sensititre» test system.
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