Authors
Krainyukov P.E.1,2, Artsimovich I.V.3, Zinoviev E.V.3,4, Gostimskiy A.V.3, Kostyakov D.V.3,4, Kokorin V.V.1,5, Vahaev D.S.5
1 Central Military Clinical Hospital. P.V. Mandryka of the Ministry of Defense of the Russian Federation, Moscow
2 RUDN University, Moscow
3 St. Petersburg State Pediatric Medical University, St. Petersburg
4 Research Institute Of Emergency Medecine named after I.I. Djanelidzе, St. Petersburg
5 Pirogov National Medical and Surgical Center, Moscow
Abstract
The active development of tissue engineering and cell technologies has allowed us to develop new methods of treating wounds of various etiologies. The advances made in the study of human stem cell biology in vitro and in vivo experimental models in recent decades could not fail to attract the attention of practitioners. Embryonic stem cells, mesenchymal stem cells, adipogenic mesenchymal stem cells, and hematopoietic stem cells are currently being studied most intensively. Gradually, the possibilities of biotechnological restoration of the skin are being introduced into practice both in our country and abroad. Every year, the number of clinical trials conducted in different countries of the world is steadily growing. Many researchers note the effectiveness of the use of stem cells in the treatment of full-layer skin defects. However, the issues of choosing the ideal source of stem cells and the method of their delivery to the wound defect area remain unresolved. Further experimental and clinical studies of the effectiveness of the use of stem cells and the evaluation of their effect on reparative histogenesis are required.
Keywords: stem, mesenchymal, cell, wound, burn, repair, engineering, technology.
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