DOI: 10.25881/20728255_2024_19_4_S1_96

Authors

Zakirov R.M.1, 2, Sabirova I.H.1, Zhidenko E.A.1, Sabirova L.N.2

1 State Autonomous Healthcare Institution «RCOH of the Ministry of Health of the Republic of Tatarstan named after Professor E.V. Adamyuk», Kazan

2 KSMA – Branch Campus of the FSBEIFPE RMACPE MOH Russia, Kazan

Abstract

The difficulty of diagnosing Vogt-Koyanagi-Harada syndrome is due to the fact that in the prodromal stage, the inflammatory process develops in the vascular membrane without ocular manifestations, clinically, flu-like syndrome, meningism come out in the first place, mistakenly leading the patient to a doctor of another specialty.

Objective: To analyze optical coherence tomography (OCT) data and clinical manifestations for early diagnosis and timely treatment of Vogt-Koyanagi-Harada syndrome.

Methods: Data from two clinical cases are presented: patient T. with timely pathogenetic pulse therapy and patient B. with alternative treatment due to his refusal of the proposed therapy.

Results: Against the background of treatment, both patients have an increase in visual acuity, but patient B. has a less favorable prognosis according to OCT data due to the lack of adequate therapy

Conclusion: OCT of the macular region makes it possible to make the correct diagnosis at an early date, which prevents the transition of the uveitic stage of Vogt-Koyanagi-Harada disease into a chronic one.

Keywords: Vogt-Koyanagi-Harada disease, optical coherence tomography, exudative retinal detachment, retinal pigment epithelium hyperplasia.

References

1. Kanski Dzh.Dzh., Milevski S.A., Damato B.E., Tenner V. Zabolevaniya glaznogo dna. – Per. s angl. – 2‑e izd. ⁄ Pod obshch. red. chl.‑korr. RAMN, prof. S.E. Avetisova. – M.: MEDpress‑inform, 2009. – 424 s., il.

2. Fedotov V. P. Rasstroistva pigmentatsii kozhi (diskhromii)//DVKS. 2014. (In Russ.)

3. Katargina L. A., Denisova E. V., Starikova A. V., Gvozdyuk N. A. Clinical findings and treatment results in the Vogt-Koyanagi-Harada syndrome associated uveitis in children. Oftal’mologicheskie vedomosti. 2012; 5 (1): 36-44. (In Russ.)

4. Senchenko N. YA., SHCHuko A. G., Malyshev V. V. Uveity: rukovodstvo. M.: GEOTAR-Media; 2010.

5. Kacnel'son L.A., Tankovskij V.E. Uveity (klinika, lechenie).– M., 1998. – 203 s.

6. Bodmer W. //HLA 1997 Eds P.Terasaki, D.Gjertson. – 1998. – P. 1–7.

7. Boutimzine N., Laghmari A., Ouazzani I., Ibrahimy W., Mohcine Z. // J. Fr. Ophtalmol. – 1998. – Dec; 21 (10). – P. 746–754

8. Desarnaulds–A.B., Borruat–F.X., Herbort–C.P., Spertini–F. //Klin.–Monatsbl.–Augenheilkd. – 1996. – May. – 208 (5). – P. 301–302.

9. Mambetkulova G. K., Ishberdina L. Sh., Mal’khanov V. B. Immunologicheskie i immunogeneticheskie osobennosti uveitov pri sindrome Fogta-Koyanagi-Kharada. Russkii meditsinskii zhurnal. (In Russ.)

10. Rao N. A., Sukavatcharin S., Tsai J. H. Vogt-Koyanagi-Harada disease diagnostic criteria. Int. Ophthalmol. 2007; 27 (2-3): 195-9.8.2024).

For citation

Zakirov R.M., Sabirova I.H., Zhidenko E.A., Sabirova L.N. Analysis of early changes in optical coherence tomography and ocular manifestations of Vogt-Koyanagi-Harada disease (clinical cases). Bulletin of Pirogov National Medical & Surgical Center. 2024;19(4,supplement):96-99. (In Russ.) https://doi.org/10.25881/20728255_2024_19_4_S1_96