The possibilities of using hyperbaric oxygenation in the complex treatment of patients with malignant tumors

Surov D.A., Konoplev N.A., Alimov P.A., Rudakov D.A., Eselevich R.V.

Due to the high mortality rate from oncological diseases, the world medical community continues to work on methods of treatment and prevention of complications associated with the treatment of malignant neoplasms. However, not enough attention is paid to the active study of some scientifically based ways to fight cancer. One of such effective and little-studied methods of influencing the processes of carcinogenesis is the effect on the body of increased oxygen pressure. In this regard, the analysis of scientific and research works devoted to the study of the mechanism of action and the possibility of using hyperbaric oxygenation in patients with malignant neoplasms was carried out. The results of experimental and clinical studies, during which the use of hyperbaric oxygen therapy in oncology was evaluated, are described and structured. In the course of studying the literature data, it was revealed that exposure to increased oxygen pressure leads to activation of apoptosis of tumor cells, a decrease in their proliferation and aggressiveness. In the postoperative period, the indicators of hemogram, water-electrolyte balance, acid-base state improve. Combined use with polychemotherapy helps to overcome chemotherapeutic resistance, reduce the toxic and cytostatic effects of chemotherapy drugs on the body. And the combination with radiation therapy allows the use of hyperbaric oxygenation both as a method of increasing the sensitivity of tumor cells to radiation, and as a preventive and therapeutic effect on delayed radiation lesions. Thus, the use of high oxygen pressure therapy in the complex treatment of malignant tumors leads to an increase in the quality and life expectancy of patients with neoplasms. At the same time, it is possible to use both a method of supporting basic polychemotherapy and /or radiation therapy, and a method of preventing the development and treatment of complications. However, due to the insufficiency of the conducted clinical studies, this method needs extensive multidisciplinary discussion and study both in domestic medicine and in foreign practice.

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